Answer:It is a protein reagent for biochemical research into DNA relaxation, enzyme function and inhibitor-response assays.
Answer:No. It is recombinant human Topoisomerase I protein, not an antibody.
Answer:The original Abcam product page marks this recombinant protein as discontinued; remaining stock and alternatives require separate confirmation.
Recombinant Human DNA Topoisomerase I Protein is a human enzyme preparation intended for biochemical research involving DNA topology and topoisomerase function. DNA topoisomerase I changes DNA topology by introducing and resealing transient single-strand breaks, allowing torsional stress to be relieved during processes such as transcription and replication. Purified recombinant protein can serve as an assay input for method development, inhibitor studies or reference-protein comparisons when its batch-specific quality and activity are suitable. Experimental design should distinguish protein identity from demonstrated catalytic activity, because concentration alone does not establish enzyme function. Use appropriate DNA substrates, buffer conditions and controls when investigating topoisomerase activity. Store and reconstitute the material in line with the documentation accompanying the available stock, and avoid repeated handling that might compromise protein integrity. This product is a recombinant protein reagent, not an anti-topoisomerase antibody or a ready-to-use clinical diagnostic test.
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