Description
Key facts
CAS number:616-91-1,
Purity:>99%,
Form:SolidSee storage information,
Molecular weight:163.2 Da,
Molecular formula:C5H9NO3S,
PubChem:12035,
Nature:Synthetic,
Solubility:Soluble in water to 100 mMSoluble in DMSO to 100 mM,
Biochemical name:Acetylcysteine,
Biological description:ROS inhibitor. L-cysteine prodrug. Mucolytic agent. Inhibits viral stimulation by reactive oxygen intermediates. Shows mucolytic, hepatoprotective and antiviral effects in vivo. Orally active.,
Canonical smiles:CC(=O)NC(CS)C(=O)O,
Isomeric smiles:CC(=O)N[C@@H](CS)C(=O)O,
InChi:InChI=1S/C5H9NO3S/c1-3(7)6-4(2-10)5(8)9/h4,10H,2H2,1H3,(H,6,7)(H,8,9)/t4-/m0/s1,
InChiKey:PWKSKIMOESPYIA-BYPYZUCNSA-N,
IUPAC Name:(2R)-2-acetamido-3-sulfanylpropanoic acid
Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Store under desiccating conditions, The product can be stored for up to 12 months
Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Retinoid X Receptor alpha (RXRA) also referred to as NR2B1 is a nuclear receptor with a mass of approximately 55 kDa. RXRA functions as a transcription factor and plays a significant role in regulating gene expression by forming heterodimers with other nuclear receptors. RXRA is expressed in many tissues with notable levels in organs like the liver lungs and kidneys. Its ability to bind DNA sequences known as retinoic acid response elements allows RXRA to regulate diverse physiological processes.
Biological function summary
RXRA serves an important role in metabolic regulation especially in lipid metabolism and glucose homeostasis. It forms heterodimers with partners such as peroxisome proliferator-activated receptors (PPARs) enhancing its capacity to modulate various metabolic pathways. These heterodimers facilitate the transcription of genes that respond to nutritional changes. RXRA also influences immune responses and cell differentiation making it important for maintaining cellular health.
Pathways
RXRA operates within the retinoid signaling and lipid metabolism pathways. Through its interaction with PPARs particularly PPAR-γ and PPAR-α RXRA becomes an integral part of the signaling that controls fatty acid storage and glucose metabolism. These pathways influence cellular function and energy balance impacting the body's overall metabolic status.
RXRA has associations with metabolic diseases such as diabetes and cardiovascular disorders. Dysregulation of RXRA expression or function can disrupt lipid and glucose metabolism leading to insulin resistance and metabolic syndrome. The RXRA-PPAR-γ interaction is essential in these conditions with the pair influencing adipogenesis and inflammatory responses. Understanding and targeting RXRA interactions can provide therapeutic prospects for these metabolic disorders.
