Description
Key facts
CAS number:142340-99-6,
Purity:>99%,
Molecular weight:501.5 Da,
Molecular formula:C20H32N5O8P,
PubChem:60871,
Nature:Synthetic,
Solubility:Soluble in ethanol to 100 mMSoluble in DMSO to 100 mM,
Biochemical name:Adefovir dipivoxil,
Biological description:Potent, selective, nucleotide analog reverse transcriptase inhibitor. Inhibits viral DNA synthesis (IC50 = 0.2-2.5 μM, HBV transfected human hepatoma cell lines). Shows antiviral effects in vivo. Orally active.,
Canonical smiles:CC(C)(C)C(=O)OCOP(=O)(COCCN1C=NC2=C(N=CN=C21)N)OCOC(=O)C(C)(C)C,
InChi:InChI=1S/C20H32N5O8P/c1-19(2,3)17(26)30-11-32-34(28,33-12-31-18(27)20(4,5)6)13-29-8-7-25-10-24-14-15(21)22-9-23-16(14)25/h9-10H,7-8,11-13H2,1-6H3,(H2,21,22,23),
InChiKey:WOZSCQDILHKSGG-UHFFFAOYSA-N,
IUPAC Name:[2-(6-aminopurin-9-yl)ethoxymethyl-(2,2-dimethylpropanoyloxymethoxy)phosphoryl]oxymethyl 2,2-dimethylpropanoate
Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate long-term storage conditions-+4°C, Storage information-Store under desiccating conditions, The product can be stored for up to 12 months
Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Gli3 also known as GLI-Kruppel family member 3 is a transcription factor part of the Gli protein family. It weighs approximately 170 kDa. Gli3 is expressed in various tissues including the brain lungs and limbs. It modulates gene expression important for organ development and differentiation. Gli3 can function as both a repressor and an activator of transcription depending on its processing into a shorter repressor form or remaining a full-length activator form.
Biological function summary
Gli3 participates in the regulation of embryonic patterning where it plays roles in limb and central nervous system development. It does not usually act alone; instead it is part of the Hedgehog signaling pathway complex which includes related proteins like Gli1 and Gli2. Through differential processing Gli3 contributes to the fine-tuning of Hedgehog pathway outputs controlling tissue-specific gene expression necessary for proper morphogenesis.
Pathways
Gli3 plays an integral role in the Hedgehog signaling pathway and interacts heavily within this pathway. It regulates genes that control cell growth cell specialization and stem cell maintenance. Gli3's activity within these pathways is closely tied to proteins such as Sonic Hedgehog (Shh) which modulates its repressor and activator forms. The precise function of Gli3 in the pathway significantly impacts developmental processes and tissue patterning.
Alterations in Gli3 function or expression link to polydactyly and Pallister-Hall syndrome. Gli3 mutations can disrupt normal limb development leading to additional digits as seen in polydactyly. In these conditions Gli3 interacts with other proteins such as GLI1 and GLI2 often resulting in aberrant activation or repression of downstream targets. These interactions highlight the pathological consequences of dysregulation within the Hedgehog pathway and its related components.
