Description
Key facts
CAS number:548-62-9,
Form:PowderSee storage information,
Molecular weight:408 Da,
Molecular formula:C25H30N3.Cl,
PubChem:11057,
Nature:Synthetic,
Solubility:Soluble in water to 25 mM,Soluble in DMSO to 100 mMSoluble in ethanol to 10 mM,
Biochemical name:Gentian Violet,
Biological description:Cation-based violet dye. Interacts with aqueous KI - I2 during Gram staining to produce a precipitate. Histological stain for Gram-positive bacteria and DNA. Shows antibacterial, antifungal, and anthelmintic effects in vivo.,
Canonical smiles:CN(C)C1=CC=C(C=C1)C(=C2C=CC(=[N+](C)C)C=C2)C3=CC=C(C=C3)N(C)C.[Cl-],
InChi:InChI=1S/C25H30N3.ClH/c1-26(2)22-13-7-19(8-14-22)25(20-9-15-23(16-10-20)27(3)4)21-11-17-24(18-12-21)28(5)6;/h7-18H,1-6H3;1H/q+1;/p-1,
InChiKey:ZXJXZNDDNMQXFV-UHFFFAOYSA-M,
IUPAC Name:[4-[bis[4-(dimethylamino)phenyl]methylidene]cyclohexa-2,5-dien-1-ylidene]-dimethylazanium;chloride
Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Store under desiccating conditions, The product can be stored for up to 12 months
Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Tau also known as MAPT is a protein with significant roles in the nervous system. Its molecular weight ranges from 48 to 67 kDa varying due to alternative splicing. Tau is expressed mainly in neurons but also found in astrocytes and oligodendrocytes. Mechanically it stabilizes microtubules by binding to them which is essential for maintaining neural cell shape and facilitating intracellular transport. MAPK1 also known as ERK2 is a serine/threonine kinase involved in cellular functions such as proliferation and differentiation. It has a molecular weight of approximately 41 kDa and is expressed in almost all tissues.
Biological function summary
MAPT contributes to neural stability by maintaining the integrity of axonal microtubules. It is an important component of the cytoskeletal network and affects neuronal viability. MAPK1 part of the MAPK family plays important roles in relaying extracellular signals to intracellular responses. It forms part of signaling complexes that transmit growth factor signals to the nucleus affecting gene expression. Estrogen receptors found in diverse tissues like breast and brain mediate cellular responses to estrogen impacting reproductive and non-reproductive systems.
Pathways
MAPT interacts within the axon guidance pathway influencing neural development and synaptic plasticity. It's also involved in neurotrophic factor-mediated signaling. MAPK1 functions prominently within the MAPK/ERK pathway which modulates cell cycle progression and differentiation. Both proteins interact with several kinases and phosphatases including those from the ERK pathway that are important for signal transduction. Estrogen receptors engage in the PI3K/AKT and Ras/MAPK pathways regulating cell growth and survival.
Abnormal MAPT accumulation leads to tauopathies like Alzheimer's disease impacting synaptic function. It also interacts with other proteins like alpha-synuclein contributing to neurodegenerative processes. MAPK1 has been linked to various cancers due to its role in regulating cell division and proliferation. It associates with ERBB receptors in this context. Estrogen receptors relate to breast cancer where their activation influences tumor growth. Drugs targeting estrogen receptors like aromatase inhibitors are used in breast cancer treatment.
