Description
Key facts
CAS number:140651-18-9,
Purity:>95%,
Molecular weight:218.2 g/mol,
Molecular formula:C9H10N6O,
Nature:Synthetic,
Solubility:Soluble in DMSO,
Biological description:Potent, selective Cdk9 kinase inhibitor (IC50 = 350 nM). Moderate ATP-competitive Cdk2-cyclin E inhibitor (IC50 = 20 μM). Induces cell cycle arrest, decreasing S-phase. Shows antiproliferative effects (IC50 values are 33, 49, 64 and 62 μM for MCF7, HOS, G361, and K562 cells respectively).,
Isomeric smiles:NC2NNC(N)C2/N=N/C1CCC(O)CC1,
InChi:InChI=1S/C9H10N6O/c10-8-7(9(11)15-14-8)13-12-5-1-3-6(16)4-2-5/h1-4,16H,(H5,10,11,14,15)/b13-12+,
InChiKey:AYZRKFOEZQBUEA-OUKQBFOZSA-N,
IUPAC Name:4-[(E)-(3,5-Diamino-1H-pyrazol-4-yl)diazenyl]phenol
Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store under desiccating conditions, The product can be stored for up to 12 months
