Description
Key facts
CAS number:171009-07-7,
Purity:>98%,
Form:SolidSee storage information,
Molecular weight:352.39 g/mol,
Molecular formula:C20H20N2O4,
Nature:Synthetic,
Solubility:Soluble in ethanol to 100 mMSoluble in DMSO to 100 mM,
Biological description:Selective, cell-permeable Hsp90 ATPase inhibitor (IC50 values are 3.2 μM and 6.6 μM for Human Hsp90 beta and yeast Hsp90 respectively). Exhibits no detectable effects against Human Hsp72 ATPase or topoisomerase II. Shows antiproliferative effects. Upregulates Hsp72 and downregulates c-Raf and cdk4. Antitumor activity is independent of NQO1/DT-diaphorase and P-glycoprotein expression.,
Canonical smiles:CCC1CC(C(CC1O)O)C2C(C([NH]N2)C)C3CCC4C(C3)OCCO4,
InChi:InChI=1S/C20H20N2O4/c1-3-12-8-14(16(24)10-15(12)23)20-19(11(2)21-22-20)13-4-5-17-18(9-13)26-7-6-25-17/h4-5,8-10,23-24H,3,6-7H2,1-2H3,(H,21,22),
InChiKey:OWPMENVYXDJDOW-UHFFFAOYSA-N,
IUPAC Name:4-[4-(2,3-Dihydro-1,4-benzodioxin-6-yl)-5-methyl-1H-pyrazol-3-yl]-6-ethyl-1,3-benzenediol
Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C
