Description
Key facts
CAS number:247580-43-4,
Form:LiquidSee storage information,
Molecular weight:378.4 Da,
Molecular formula:C21H18N2O5,
PubChem:10474776,
Nature:Synthetic,
Biochemical name:methyl (2S)-2-(naphthalene-2-carbonylamino)-3-(4-nitrophenyl)propanoate,
Biological description:A highly potent and selective CC chemokine receptor-3 (CCR3) antagonist (IC50 = 4 nM). Shows >2500-fold selectivity over CCR7, CXCR1, CXCR2, C4aR and LTD4 receptors. Inhibits Ca2+ mobilization induced by eotaxin, eotaxin-2 and MCP-4 (IC50 values are 38, 35, and 20 nM, respectively). Also inhibits eosinophil chemotaxis.,
Canonical smiles:COC(=O)C(CC1=CC=C(C=C1)[N+](=O)[O-])NC(=O)C2=CC=CC3=CC=CC=C32,
Isomeric smiles:COC(=O)[C@H](CC1=CC=C(C=C1)[N+](=O)[O-])NC(=O)C2=CC=CC3=CC=CC=C32,
InChi:InChI=1S/C21H18N2O5/c1-28-21(25)19(13-14-9-11-16(12-10-14)23(26)27)22-20(24)18-8-4-6-15-5-2-3-7-17(15)18/h2-12,19H,13H2,1H3,(H,22,24)/t19-/m0/s1,
InChiKey:VMFGCGRAIBLAFY-IBGZPJMESA-N,
IUPAC Name:methyl (2S)-2-(naphthalene-1-carbonylamino)-3-(4-nitrophenyl)propanoate
Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store in the dark, Store under desiccating conditions
