Abcam, ab187587-100Test, Alexa Fluor® 488 Anti-HLA A2 antibody [BB7.2]

Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
HLA A2 contributes to the adaptive immune response by presenting antigenic peptides derived from intracellular proteins to CD8+ cytotoxic T lymphocytes. It forms a heterotrimeric complex that includes HLA heavy chain β2-microglobulin and a peptide of approximately 8-10 amino acids. This complex is fundamental for the recognition of infected or transformed cells facilitating their destruction by the immune system.
Pathways
The target engages in immune response pathways especially the antigen processing and presentation pathway. It shares functions with other HLA class I molecules such as HLA-B and HLA-C which together coordinate the presentation of a diverse array of peptides to cytotoxic T cells. Moreover HLA A2 plays a role in the T-cell receptor signaling pathway which is important for the activation of immune responses.