Abcam, ab199086-100µL, Alexa Fluor® 488 Anti-alpha + beta Synuclein antibody [EP1646Y]

Product details
Patented technology Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.
Alexa Fluor® is a registered trademark of Molecular Probes, Inc, a Thermo Fisher Scientific Company. The Alexa Fluor® dye included in this product is provided under an intellectual property license from Life Technologies Corporation. As this product contains the Alexa Fluor® dye, the purchase of this product conveys to the buyer the non-transferable right to use the purchased product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). As this product contains the Alexa Fluor® dye the sale of this product is expressly conditioned on the buyer not using the product or its components, or any materials made using the product or its components, in any activity to generate revenue, which may include, but is not limited to use of the product or its components: in manufacturing; (ii) to provide a service, information, or data in return for payment (iii) for therapeutic, diagnostic or prophylactic purposes; or (iv) for resale, regardless of whether they are sold for use in research. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or [email protected].

Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
Alpha- and beta-synuclein play roles in synaptic function and plasticity where they influence neurotransmitter release and vesicle recycling. These proteins do not generally form a stable complex with each other but their presence together suggests a regulatory interplay. Alpha-synuclein may promote vesicle formation and trafficking while beta-synuclein appears to counteract alpha's effects potentially protecting neurons from alpha-synuclein aggregation.
Pathways
Alpha- and beta-synuclein are key components in the synaptic vesicle cycle especially associated with the SNARE complex and neurotransmitter balance. Alpha-synuclein interacts with proteins like VAMP2 and STX1A in vesicle merging while beta-synuclein's regulatory role has implications in maintaining these interactions. In lipid metabolism alpha-synuclein influences fatty acid binding protein pathways impacting neuronal lipid transport and homeostasis.