Description
Product details
What is this antibody validated in? Alexa Fluor® 488 Anti-alpha smooth muscle Actin antibody [EPR5368] (ab202295) is a rabbit recombinant monoclonal antibody and is validated for use in Immunocytochemistry/immunofluorescence (ICC/IF) in Human, Mouse, Rat samples. Related products Antibody clone EPR5368 is also available pre-conjugated to a variety of labels for your convenience – Anti-alpha smooth muscle Actin Alexa Fluor® 488 [EPR5368] (ab202295). Specificity confirmed The specificity of Alexa Fluor® 488 Anti-alpha smooth muscle Actin antibody [EPR5368] (ab202295) has been confirmed by Immunocytochemistry testing in ACTA2 Knockout HeLa cells. Other related products We have a range of other formats of antibody clone [EPR5368] also available for your convenience: ab124964, Alexa Fluor® 488 - ab202295, Alexa Fluor® 647 - ab202296, Alexa Fluor® 555 - ab202509, Alexa Fluor® 594 - ab202510, PE - ab208844, Carrier free - ab220795, APC - ab225143, ab284414, Alexa Fluor® 790 - ab309335, ab320058, Carrier free - ab320059, ab321866, Carrier free - ab322917
Patented technology Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
Alpha smooth muscle actin aids in maintaining the structural integrity of tissues by forming part of the actin cytoskeleton an important element in cellular support. It exists in high concentration in stress fibers contributing to cellular movements and shape maintenance. These actions are essential in various dynamic cellular processes such as cell migration and adhesion. Alpha smooth muscle actin does not typically form complexes but it associates with other components of the actin cytoskeleton to ensure cell stability and function.
Pathways
Alpha smooth muscle actin functions significantly within the TGF-beta signaling pathway which influences cell proliferation differentiation and apoptosis. It interacts closely with proteins such as myosin to facilitate cellular contractility and motility. Additionally α-SMA plays a part in the RhoA/Rho kinase (ROCK) pathway connecting with regulators of actin filament organization. These pathways are essential for modulation of smooth muscle contraction and actin filament assembly contributing to vascular development and wound healing.