Description
Key facts
CAS number:1616391-65-1,
Purity:>98%,
Form:SolidSee storage information,
Molecular weight:383.4 Da,
Molecular formula:C20H25N5O3,
PubChem:90241673,
Nature:Synthetic,
Solubility:Soluble in DMSO to 50 mM,
Biochemical name:(S)-N-(3-(3,4-Dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-6-(oxetan-3-ylamino)pyrimidine-4-carboxamide,
Biological description:Selective, potent (IC50 = 22nM, Ki =5 nM) inhibitor of arginine methyltransferase 5 (PRMT5). Displays selectivity for PRMT5 over a panel of 20 other protein methyltransferases.,
Canonical smiles:C1CN(CC2=CC=CC=C21)CC(CNC(=O)C3=CC(=NC=N3)NC4COC4)O,
Isomeric smiles:C1CN(CC2=CC=CC=C21)C[C@H](CNC(=O)C3=CC(=NC=N3)NC4COC4)O,
InChi:InChI=1S/C20H25N5O3/c26-17(10-25-6-5-14-3-1-2-4-15(14)9-25)8-21-20(27)18-7-19(23-13-22-18)24-16-11-28-12-16/h1-4,7,13,16-17,26H,5-6,8-12H2,(H,21,27)(H,22,23,24)/t17-/m0/s1,
InChiKey:ZKXZLIFRWWKZRY-KRWDZBQOSA-N,
IUPAC Name:N-[(2S)-3-(3,4-dihydro-1H-isoquinolin-2-yl)-2-hydroxypropyl]-6-(oxetan-3-ylamino)pyrimidine-4-carboxamide
Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store under desiccating conditions
