Abcam, ab256469-1mL, Anti-Cleaved Caspase-7 antibody [EPR22840-25]

Product details
Patented technology Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.
What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on recombinant antibodies.

Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
Cleaved Caspase-7 plays a role by executing apoptosis through cleaving cellular substrates after aspartic acid residues. It operates independently or as part of the apoptosome complex which includes other caspases and protein factors. This complex contributes to the orderly dismantling of cellular structures during programmed cell death ensuring the removal of damaged or unnecessary cells in a controlled manner.
Pathways
Cleaved Caspase-7 participates actively in the apoptosis signaling pathway and to a lesser extent in the inflammatory response. It acts downstream in the cascade initiated by pro-apoptotic signals wherein it shares significant functional similarities with Caspase-3. Together with Caspase-8 which acts earlier in the pathway these proteins form a network that ensures the fidelity of programmed cell death. Caspase-8 initiates the cascade leading to the activation of Caspase-7.