Description
Key facts
CAS number:670220-88-9,
Purity:97%,
Form:SolidSee storage information,
Molecular weight:443.5 Da,
Molecular formula:C26H29N5O2,
PubChem:10366136,
Nature:Synthetic,
Solubility:Soluble in DMSO to 25 mMSoluble in ethanol to 10 mM,
Biochemical name:Crenolanib,
Biological description:Potent inhibitor of PDGFR (Kd for alpha = 2.1 nM; beta = 3.2 nM) and FLT3 (Kd = 0.74 nM). Type I inhibitor that binds only the active kinase conformation. Active towards imatinib-resistance assciated PDGFR-alpha mutations (D842I, D842V, D842Y, DI842-843M, and deletion I843). Active against FLT3/ITD and FLY3/D835 mutatants. Over 100-fold selective for PDGFR versus c-Kit, VEGFR-2, TIE-2, FGFR-2, EGFR, erbB2, and Src.,
Canonical smiles:CC1(COC1)COC2=CC3=C(C=C2)N(C=N3)C4=NC5=C(C=CC=C5N6CCC(CC6)N)C=C4,
InChi:InChI=1S/C26H29N5O2/c1-26(14-32-15-26)16-33-20-6-7-22-21(13-20)28-17-31(22)24-8-5-18-3-2-4-23(25(18)29-24)30-11-9-19(27)10-12-30/h2-8,13,17,19H,9-12,14-16,27H2,1H3,
InChiKey:DYNHJHQFHQTFTP-UHFFFAOYSA-N,
IUPAC Name:1-[2-[5-[(3-methyloxetan-3-yl)methoxy]benzimidazol-1-yl]quinolin-8-yl]piperidin-4-amine
Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C
Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Calcium/calmodulin-dependent protein kinase II (CaMKII) phosphorylase kinase gamma 2 (PHKG2) mitogen-activated protein kinase kinase kinase kinase 5 (MAP4K5) MAP4K3/GLK (germinal center kinase-like kinase) and glycyl-tRNA synthetase (GARS) are distinct but functionally significant proteins in cellular signaling and metabolism. CaMKII also known as CAM2K exhibits a mass approximately of 50-60 kDa and expresses in many tissues especially in the brain and heart. PHKG2 with a mass around 44 kDa participates mainly in liver and skeletal muscles. MAP4K5 and MAP4K3 also known as KHS and GLK respectively express throughout various tissues with masses near 100 kDa. GARS a component of the aminoacyl-tRNA synthetase family weighs about 83 kDa and shows presence in cytoplasm.
Biological function summary
These proteins serve as significant modulators of cellular activities. CaMKII plays a role in calcium ion signaling and associates with L-type calcium channel complex enhancing signal transduction. PHKG2 regulates glycogen metabolism being part of a complex involved in glycogen breakdown. MAP4K5 and MAP4K3 function in stress-activated protein kinase pathways taking part in immune responses and cell apoptosis. GARS joins protein synthesis machinery by catalyzing the attachment of glycine to its corresponding transfer RNA.
Pathways
These proteins integrate into essential signaling and metabolic routes. CaMKII influences the calcium/calmodulin signaling pathway affecting brain functions and cardiac contractility relating closely to proteins like calmodulin and synapsin. PHKG2 fits into the glycogen degradation pathway interacting with partners such as phosphorylase kinase beta. MAP4K5 and MAP4K3 engage in the JNK signaling cascade essential for inflammatory response linking with MAPK and AP-1 transcription factors. GARS operates within the protein biosynthesis pathway connecting to elongation factors to ensure accurate amino acid incorporation.
These proteins exhibit associations with various pathological states. CaMKII relates to cardiac hypertrophy and Alzheimer’s disease with links to tau protein contributing to neurofibrillary tangles. Mutations in PHKG2 cause glycogen storage disease type IXa affecting energy metabolism and interacting with the enzyme glycogen phosphorylase. MAP4K5 and MAP4K3 show connections to inflammatory bowel disease due to their role in JNK-mediated inflammation. GARS mutations lead to Charcot-Marie-Tooth disease a peripheral neuropathy disorder involving connections to protein misfolding pathways.
