Description
Key facts
CAS number:905281-76-7,
Purity:>98%,
Form:SolidSee storage information,
Molecular weight:334.4 Da,
Molecular formula:C19H18N4O2,
PubChem:11717001,
Nature:Synthetic,
Solubility:Soluble in DMSO to 50 mM,
Biochemical name:(E)-5-(1-(2-hydroxyethyl)-3-(pyridin-4-yl)-1H-pyrazol-4-yl)-2,3-dihydro-1H-inden-1-one oxime,
Biological description:Potent and selective B-Raf inhibitor (IC50 = 0.13 nM against purified V600E enzyme). Inhibits cellular pERK (IC50 = 63 nM). Blocks Raf/MEK/ERK signaling in B-Raf V600E mutant cell lines. Highly selective against a panel of 140 full-length protein kinases.,
Canonical smiles:C1CC(=NO)C2=C1C=C(C=C2)C3=CN(N=C3C4=CC=NC=C4)CCO,
Isomeric smiles:C1C/C(=N\O)/C2=C1C=C(C=C2)C3=CN(N=C3C4=CC=NC=C4)CCO,
InChi:InChI=1S/C19H18N4O2/c24-10-9-23-12-17(19(21-23)13-5-7-20-8-6-13)15-1-3-16-14(11-15)2-4-18(16)22-25/h1,3,5-8,11-12,24-25H,2,4,9-10H2/b22-18+,
InChiKey:DEZZLWQELQORIU-RELWKKBWSA-N,
IUPAC Name:2-[4-[(1E)-1-hydroxyimino-2,3-dihydroinden-5-yl]-3-pyridin-4-ylpyrazol-1-yl]ethanol
Product details:
For obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20°C for several months.
Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C
