Description
Key facts
CAS number:848695-25-0,
Purity:>98%,
Form:SolidSee storage information,
Molecular weight:318.76 Da,
Molecular formula:C14H15ClN6O,
PubChem:16736529,
Nature:Synthetic,
Solubility:Soluble in DMSO to 100 mM,
Biochemical name:6-chloro-9-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-9H-purin-2-amine,
Biological description:Selective, Hsp90 competitive inhibitor (Ki = 1.7 nM). Displays no significant activity at a range of ATP-binding kinases or Na+K+ ATPase. Induces degradation of HER-2 in vitro (EC50 = 38 nM in MCF-7 cells). Inhibits growth and promotes cell death in a variety of human tumor cells. Orally bioavailable.,
Canonical smiles:CC1=CN=C(C(=C1OC)C)CN2C=NC3=C2N=C(N=C3Cl)N,
InChi:InChI=1S/C14H15ClN6O/c1-7-4-17-9(8(2)11(7)22-3)5-21-6-18-10-12(15)19-14(16)20-13(10)21/h4,6H,5H2,1-3H3,(H2,16,19,20),
InChiKey:QULDDKSCVCJTPV-UHFFFAOYSA-N,
IUPAC Name:6-chloro-9-[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]purin-2-amine
Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C
