Description
Key facts
CAS number:888216-25-9,
Purity:>98%,
Form:SolidSee storage information,
Molecular weight:364.4 Da,
Molecular formula:C20H20N4O3,
PubChem:135564985,
Nature:Synthetic,
Solubility:Soluble in DMSO to 100 mM,
Biochemical name:Ganetespib,
Biological description:Potent Hsp90 inhibitor (IC50 of 4nM in OSA 8 cells). Causes cytotoxicity in a variety of hematological and solid tumor cell lines by causing degradation of multiple oncogenic Hsp90 client proteins. Ganetespib inhibits MG63 cell lines with IC50 of 43 nM.,
Canonical smiles:CC(C)C1=C(C=C(C(=C1)C2=NNC(=O)N2C3=CC4=C(C=C3)N(C=C4)C)O)O,
InChi:InChI=1S/C20H20N4O3/c1-11(2)14-9-15(18(26)10-17(14)25)19-21-22-20(27)24(19)13-4-5-16-12(8-13)6-7-23(16)3/h4-11,25-26H,1-3H3,(H,22,27),
InChiKey:RVAQIUULWULRNW-UHFFFAOYSA-N,
IUPAC Name:3-(2,4-dihydroxy-5-propan-2-ylphenyl)-4-(1-methylindol-5-yl)-1H-1,2,4-triazol-5-one
Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C
