Description
Key facts
Purity:>90% SDS-PAGE,
Endotoxin level:< 1 EU/µg,
Expression system:HEK 293 cells,
Tags:His tag C-Terminus,
Applications:SDS-PAGE, FuncSSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:Yes,
Biological activity:Measured by its binding ability in a functional ELISA. Immobilized human TMED1-His at 10 μg/mL (100 μL/well) can bind human IL1R4-Fc, the EC50 of human IL1R4-Fc is 8-50 ng/mL.,
Accession:Q13445,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 7.4Constituents: 100% PBS
Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle
Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TMED1 also known as Transmembrane Emp24 Protein Transport Domain Containing 1 is a protein with a mass of approximately 26 kDa. It plays a role in the transport and sorting processes within the cell primarily in the endoplasmic reticulum (ER) and Golgi apparatus. TMED1 belongs to the p24 family of proteins which are involved in vesicle trafficking. In humans TMED1 is expressed in various tissues with the highest levels found in the liver kidney and pancreas.
Biological function summary
TMED1 participates in the formation of coat protein complex II (COPII) vesicles. It serves as an integral part of the cellular machinery which facilitates the transport of cargo molecules from the ER to the Golgi apparatus. This protein is essential in the early secretory pathway where it helps ensure the fidelity of cargo selection and transport. TMED1 often functions as a part of larger protein complexes interacting with other members of the p24 family to maintain vesicle integrity and efficiency.
Pathways
TMED1 takes part in the secretory pathway and to some extent the calcium-signaling pathway. It coordinates with proteins such as SEC23 and SEC24 that are important in COPII vesicle budding at the ER membrane. TMED1's role ensures that proteins meant for secretion or membrane insertion are efficiently sorted and forwarded along the secretory route to their destination. By participating in these pathways TMED1 maintains cellular homeostasis and proper protein distribution.
TMED1 has been associated with Alzheimer's Disease and certain types of cancer. In Alzheimer's TMED1 interacts with the amyloid precursor protein (APP) influencing its processing and the production of amyloid-beta an important component in disease pathology. Regarding cancer TMED1 influences cell proliferation and tumor progression through its interactions with various proteins involved in the regulation of cell cycle and apoptosis. Understanding its biological roles provides insights into its potential as a therapeutic target for these conditions.
