Description
Key facts
CAS number:1628260-79-6,
Purity:>98%,
Form:SolidSee storage information,
Molecular weight:588.7 Da,
Molecular formula:C30H33FN8O2S,
PubChem:90420193,
Nature:Synthetic,
Solubility:Soluble in DMSO,
Biochemical name:Ziritaxestat,
Biological description:Selective autotaxin inhibitor with potential application in idiopathic pulmonary disease (IPF).,
Canonical smiles:CCC1=C(N2C=C(C=C(C2=N1)C)N3CCN(CC3)CC(=O)N4CC(C4)O)N(C)C5=NC(=C(S5)C#N)C6=CC=C(C=C6)F,
InChi:InChI=1S/C30H33FN8O2S/c1-4-24-29(35(3)30-34-27(25(14-32)42-30)20-5-7-21(31)8-6-20)39-15-22(13-19(2)28(39)33-24)37-11-9-36(10-12-37)18-26(41)38-16-23(40)17-38/h5-8,13,15,23,40H,4,9-12,16-18H2,1-3H3,
InChiKey:REQQVBGILUTQNN-UHFFFAOYSA-N,
IUPAC Name:2-[[2-ethyl-6-[4-[2-(3-hydroxyazetidin-1-yl)-2-oxoethyl]piperazin-1-yl]-8-methylimidazo[1,2-a]pyridin-3-yl]-methylamino]-4-(4-fluorophenyl)-1,3-thiazole-5-carbonitrile
Product details:
This product is manufactured by BioVision, an Abcam company and was previously called B1850 GLPG-1690. B1850-25 is the same size as the 25 mg size of ab285398.
Protect from air and light.
Properties and Storage Information:
Shipped at conditions-Blue Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store in the dark, This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes
Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ENPP2 also known as Autotaxin (ATX) is a multifunctional enzyme with phosphodiesterase activity. It breaks down lysophosphatidylcholine into lysophosphatidic acid (LPA) and glycerol phosphate. With a molecular mass of approximately 100 kDa ENPP2 is secreted into extracellular environments. This protein is mainly expressed in adipose tissue but researchers found its presence in other tissues such as the brain and the liver as well.
Biological function summary
ENPP2/ATX plays an important role in processes like cell proliferation migration and survival by producing LPA a bioactive lysophospholipid. LPA acts as a signaling molecule by binding to its specific G-protein-coupled receptors. ENPP2 exists as a monomer and does not form a stable part of a larger protein structure. Its enzymatic activity in generating LPA influences various cellular responses and physiologic states.
Pathways
It is evident that ENPP2 is involved in the LPA signaling pathway and metabolic processes related to phospholipids. The LPA signaling pathway in particular links ENPP2 to proteins such as LPAR1 and LPAR2 which bind LPA and initiate downstream effects. ENPP2's enzymatic product LPA further participates in pathways influencing cellular responses like inflammation and angiogenesis.
Research highlights ENPP2's involvement in diseases such as cancer and fibrosis. ENPP2 activity is upregulated in several cancers leading to enhanced tumor cell motility and invasion. It is also linked to fibrosis particularly liver fibrosis due to its role in producing LPA which promotes fibrotic responses. In the context of these diseases ENPP2 interacts with proteins like MMPs (matrix metalloproteinases) in cancer invasion exemplifying its contribution to pathological conditions.
