Description
Key facts
Detection method:Colorimetric,
Sample types:Plasma, Tissue Homogenate, Serum, Other biological fluids,
Assay type:Competitive,
Sensitivity:< 4.688 pg/mL,
Range:7.813 - 500 pg/mL,
Assay Platform:Microplate (12 x 8 well strips)
Product details:
This Adrenaline ELISA kit, ab287788, (previously known as Adrenaline/Epinephrine ELISA kit, E4359) is a competitive ELISA assay for the quantitative measurement of Adrenaline in serum, plasma, and cell culture supernatants. The density of color is inversely proportional to the amount of Adrenaline captured from the samples.
This product is manufactured by BioVision, an Abcam company and was previously called E4359 Adrenaline/Epinephrine (EPI) ELISA Kit. E4359-100 is the same size as the 96 test size of ab287788.
Properties and Storage Information:
Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-+4°C
Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Adrenaline also known as epinephrine is a hormone and neurotransmitter with a molecular weight of approximately 183.2 g/mol. It is produced mainly in the adrenal medulla and released into the bloodstream during stress or low blood glucose levels. Adrenaline plays a mechanical role by binding to adrenergic receptors triggering a series of intracellular events that lead to physiological responses such as increased heart rate muscle strength blood pressure and sugar metabolism.
Biological function summary
Adrenaline acts as a critical mediator of the fight-or-flight response increasing energy availability and redirecting blood flow to essential organs. It operates independently rather than as part of a complex. Its biological effects also extend to the central nervous system where it modulates attention and arousal levels. This systemic regulation is essential for the body to respond swiftly to external stressors by mobilizing energy reserves and enhancing physical capabilities.
Pathways
Adrenaline exerts influence in important signaling routes such as the adrenergic receptor pathway and the cAMP signaling pathway. Through these pathways it interacts with proteins like adenylate cyclase and protein kinase A which help propagate the signal within the cell leading to various physiological effects. These pathways help the organism maintain homeostasis during periods of stress by rapidly adjusting metabolic and cardiovascular functions.
Adrenaline is implicated in the management of conditions like asthma and cardiac arrest. During an asthma attack overproduction or heightened sensitivity to adrenaline can exacerbate symptoms by causing bronchial muscles to tighten. In cardiac arrest adrenergic drugs are administered to stimulate the heart. Adrenaline levels can be influenced by other proteins such as beta-adrenergic receptors which are targets for drugs that treat these conditions by modulating adrenaline's effects on the cardiovascular and respiratory systems.
