Product detailsPatented technology Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.
What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on recombinant antibodies.
Alexa Fluor® is a registered trademark of Molecular Probes, Inc, a Thermo Fisher Scientific Company. The Alexa Fluor® dye included in this product is provided under an intellectual property license from Life Technologies Corporation. As this product contains the Alexa Fluor® dye, the purchase of this product conveys to the buyer the non-transferable right to use the purchased product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). As this product contains the Alexa Fluor® dye the sale of this product is expressly conditioned on the buyer not using the product or its components, or any materials made using the product or its components, in any activity to generate revenue, which may include, but is not limited to use of the product or its components: in manufacturing; (ii) to provide a service, information, or data in return for payment (iii) for therapeutic, diagnostic or prophylactic purposes; or (iv) for resale, regardless of whether they are sold for use in research. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or
[email protected].
Supplementary informationThis supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
The molecule acts as an important mediator in the immune response by recruiting and activating neutrophils eosinophils and other leukocytes. It supports inflammatory responses particularly in allergic reactions and autoimmunity. While not a part of a traditional complex MIP-1 alpha directly interacts with its receptors to initiate immune signaling pathways. Its expression can be upregulated by pro-inflammatory cytokines thereby enhancing its biological effects during immune system activation.
Pathways
MIP-1 alpha is closely intertwined in the chemokine signaling pathway and plays an important role in the inflammatory response pathway. Within these pathways MIP-1 alpha coordinates with proteins like CCL5 (RANTES) and interleukin-8 facilitating the recruitment of immune cells. Its function provides a pivotal control point in the migration and activation of these cells influencing the overall immune response.
