Product detailsPatented technology Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.
What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on recombinant antibodies.
Alexa Fluor® is a registered trademark of Molecular Probes, Inc, a Thermo Fisher Scientific Company. The Alexa Fluor® dye included in this product is provided under an intellectual property license from Life Technologies Corporation. As this product contains the Alexa Fluor® dye, the purchase of this product conveys to the buyer the non-transferable right to use the purchased product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). As this product contains the Alexa Fluor® dye the sale of this product is expressly conditioned on the buyer not using the product or its components, or any materials made using the product or its components, in any activity to generate revenue, which may include, but is not limited to use of the product or its components: in manufacturing; (ii) to provide a service, information, or data in return for payment (iii) for therapeutic, diagnostic or prophylactic purposes; or (iv) for resale, regardless of whether they are sold for use in research. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or
[email protected].
Supplementary informationThis supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
IgG2 plays an essential role in the immune response by activating the complement system therefore facilitating opsonization and eventual phagocytosis of pathogens. IgG2 forms part of the immunoglobulin family complex which mediates immune responses. It exhibits lower affinity for Fc receptors on phagocytic cells compared to other IgG subclasses. This characteristic affects its ability to mediate antibody-dependent cellular cytotoxicity. Despite this IgG2 remains key in recognizing polysaccharide antigens typically found on bacterial capsules which enhances immune response specificity.
Pathways
IgG2 acts within the adaptive immune system involving humoral immunity pathways. It participates in the classical complement activation pathway leading to the destruction of antigens through membrane attack complexes. IgG2 interacts with other immunoglobulin family members including IgG1 and IgG3 through these pathways offering a comprehensive immune response. The relationship with IgM is also notable as both IgG2 and IgM are involved in the first line of defense against polysaccharide antigens.
