Product detailsPatented technology Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.
What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on recombinant antibodies.
Alexa Fluor® is a registered trademark of Molecular Probes, Inc, a Thermo Fisher Scientific Company. The Alexa Fluor® dye included in this product is provided under an intellectual property license from Life Technologies Corporation. As this product contains the Alexa Fluor® dye, the purchase of this product conveys to the buyer the non-transferable right to use the purchased product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). As this product contains the Alexa Fluor® dye the sale of this product is expressly conditioned on the buyer not using the product or its components, or any materials made using the product or its components, in any activity to generate revenue, which may include, but is not limited to use of the product or its components: in manufacturing; (ii) to provide a service, information, or data in return for payment (iii) for therapeutic, diagnostic or prophylactic purposes; or (iv) for resale, regardless of whether they are sold for use in research. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or
[email protected].
Supplementary informationThis supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
M6PR acts as a sorting receptor by binding mannose-6-phosphate-tagged enzymes in the Golgi. It is involved in a complex trafficking mechanism that involves clathrin-coated vesicles. The receptor recognizes and binds to its ligands in the Golgi directing them to endosomes and eventually fusing with lysosomes. M6PR plays a critical role in maintaining lysosome functionality by regulating enzyme availability which is essential for cellular waste degradation and resource recycling.
Pathways
The protein M6PR participates in the lysosomal enzyme targeting pathway that ensures proper enzyme sorting and delivery within cells. This pathway overlaps with the Golgi-to-endosome transport vesicle biogenesis involving proteins like clathrin and adaptin. M6PR interacts with proteins in the sorting pathway such as GGA adaptors and Hsc70 which assist in the recognition and transport processes necessary for lysosome integrity and function.
