BD, 641402, Anti-HLA-DR APC-H7 L243
100 Tests
Catalog Number: 641402
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| Verified Reactivity | Human, Mouse, Rat |
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| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Formulation | This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and 50% glycerol. |
| Preparation | The antibody was purified by antigen-affinity chromatography. |
| Concentration | Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.) |
| Storage & Handling | Upon receipt, store at -20°C. |
| Application | WB - Quality tested |
| Recommended Usage | Each lot of this antibody is quality control tested by Western blotting. Western blotting, suggested working dilution(s): Use 1:1000 - 1:4000 antibody dilution buffer for each mini-gel. It is recommended that the reagent be titrated for optimal performance for each application. |
| Application Notes | This product may contain other non-IgG subtypes. This clone is not recommended for ChIP (Chromatin Immunoprecipitation) assays (as determined by in-house testing). |
| Application References(PubMed link indicates BioLegend citation) | Fan W, et al. 2009. Brain Res Red. 59:324. PubMed Sugimoto K, et al. 2014. Neurosci Res. PubMed |
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| Product Citations | Cong J, et al. 2022. Theranostics. 12:5204. PubMed Chung H, et al. 2021. Nat Methods. 18:1204. PubMed Sugimoto K, et al. 2015. Neurosci Res. 96: 20-29. PubMed Fan W, et al. 2009. Brain Res Rev. 59:324. PubMed |
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| RRID | AB_2106632 (BioLegend Cat. No. 641401) AB_2106629 (BioLegend Cat. No. 641402) |
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| Structure | c-fos heterodimerizes with c-jun to form the transcription factor AP-1; contains a bZIP region with a DNA-binding domain and a leucine zipper domain; approximately 62 kD. |
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| Distribution | Expressed in the nucleus of many tissues/cells including placenta, brain, thyroid, central nervous system, lung, endometrium, and B lymphocytes. |
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| Function | FOS and JUN oncoproteins form dimeric complexes that stimulate transcription of genes containing AP-1 regulatory elements. FOS was the first transcription factor identified to have a critical function in the development of cells required for skeletal form |
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| Interaction | Interacts with a variety of proteins including c-jun, TFIID, NCOA2, NFAT1, CHOP, ELK1, SRC1, and ETS1 |
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| Modification | Phosphorylation on multiple sites (threonine, serine) by MAP kinases, ERK2, EphB2, PKA, Rsk. |
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| Biology Area | Cell Biology, Cell Cycle/DNA Replication, Neuroscience, Synaptic Biology, Transcription Factors |
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| Molecular Family | Nuclear Markers |
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| Antigen References | 1. Dony C, et al. 1987. Nature 328:711. 2. Grigoriadis AE, et al. 1994. Science 266:443. 3. Glover JNM, et al. 1995. Nature 373:257. |
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| Regulation | c-fos levels are highly expressed in human term fetal tissues as compared to normal human tissues. c-fos levels have been reported to be increased in patients with fibrous bone dysplasia. |
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| Gene ID | 2353 |
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| UniProt | View information about c-Fos on UniProt.org |
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| Clone | Poly6414 |
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| Regulatory Status | RUO |
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| Other Names | Oncogene Fos, FBJ murine viral (v-fos) oncogene homolog |
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| Isotype | Rabbit Polyclonal IgG |
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