Bio-Rad, AHP2561, BRCA1 (pSer988) antibody

Name: BRCA1 (pSer988) antibody
Brand: Bio-Rad
SKU: AHP2561

Size: 50 µl, Rabbit anti BRCA1 (pSer988)

Catalog Number: AHP2561

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Category

Polyclonal Antibodies

Pack Size50 µL

TagsProduct Types Polyclonal Antibody

Description

Rabbit anti BRCA1 (pSer988) antibody recognizes BRCA1, also known as breast cancer type 1 susceptibility protein and RING finger protein 53, when phosphorylated at serine 988. Breast cancer susceptibility genes BRCA1 and BRCA2 are associated with hereditary breast and ovarian cancers. BRCA1 is a tumor suppressor gene encoding an E3 ubiquitin protein ligase that plays a major role in DNA damage repair ( Roy et al. 2011 ). BRCA1 is also involved in the regulation of multiple processes including transcription and cell cycle progression. BRCA1 co-localizes with Chk2 in nuclear foci, in response to DNA damage BCRA1 is phosphorylated at serine 988 by Chk2. This phosphorylation event results in the release and dispersion of BRCA1 and is suggested to be important for the function of BRCA1 in the DNA damage response ( Lee et al. 2000 ).

Storage Information
This product is shipped at ambient temperature.
Store at -20°C
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.

Specifications

General

Target Species	Human
Product Form	Purified IgG - liquid
Preservative Stabilisers	0.02% Sodium Azide 50% Glycerol
Immunogen	Phospho specific-peptide corresponding to residues surrounding serine 988°F human BRCA1
Regulatory	For research purposes only
Guarantee	12 months from date of despatch
Product Type	Polyclonal Antibody
Isotype	Polyclonal IgG
Specificity	BRCA1 (pSer988)
Buffer Solution	Phosphate buffered saline
UniProt	P38398
Entrez Gene	BRCA1
GO Terms	GO:0007059 chromosome segregation
Antiserum Preparation	Antiserum to BRCA1 (pSer988) was raised by repeated immunization of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.

Ordering

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