Bio-Rad, AHP538, Amyloid Precursor Protein antibody

Rabbit anti Amyloid Precursor Protein antibody recognizes both intact Amyloid Precursor Protein (APP), and also the C99 fragment generated by beta-secretase. The sequence recognized by this antibody corresponds to amino acids 85-99°F the C99 fragment. The C99 fragment itself is a substrate for gamma-secretase to generate the 4 kDa beta amyloid peptide, found in the brains of Alzheimer's disease patients. APP also inhibits Notch signaling through it’s interaction with NUMB ( Roncarati et al. 2002 ). Rabbit anti Amyloid Precursor Protein antibody has been used successfully for the detection of the ~14 kDa β C-terminal fragment of APP, produced as a result of cleavage by BACE1 using western blotting -in rat retinal lysates ( Huang et al. 2012 ).

Storage Information
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.