Bio-Rad, HCA185, Bevacizumab antibody | AbD17976_hIgG1

Human Anti-Bevacizumab Antibody, clone AbD17976_hIgG1 is an affinity-matured, inhibitory, anti-idiotypic antibody that recognizes the humanized monoclonal antibody drugs bevacizumab and ranibizumab, and their biosimilar products. Clone AbD17976_hIgG1 is a fully human recombinant monoclonal antibody with IgG1 isotype and is suitable as a positive control or calibrator in an anti-drug antibody (ADA) assay. This Anti-Bevacizumab Antibody cross-reacts with the drug ranibizumab (Lucentis). Ranibizumab is a humanized Fab fragment antibody (VH3-23/kappa1), originating from the same parental mouse antibody as bevacizumab; it has 4 amino acid exchanges in the heavy chain and 1 amino acid exchange in the light chain compared to bevacizumab. Bevacizumab (trade name Avastin) is a humanized monoclonal antibody (IgG1/kappa) that inhibits angiogenesis by binding to vascular endothelial growth factor alpha (VEGF-A). VEGF-A is a potent stimulator of angiogenesis of both normal and cancerous cells, and acts as a regulator of vasculogenesis. Bevacizumab is used to treat various cancers, including colorectal, lung, breast, glioblastoma, kidney and ovarian. View a summary of all anti-bevacizumab antibodies.

Storage Information
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.