Bio-Rad, HCA335, Abatacept antibody | AbD37058ia

Human Anti-Abatacept Antibody, clone AbD37058ia is a recombinant antibody that specifically recognizes the fusion protein drug abatacept as well as cytotoxic T-lymphocyte antigen-4 (CTLA-4), also known as CD152. The antibody binds to free abatacept and can be used to measure free abatacept or abatacept biosimilars in patient samples. HCA335, clone AbD37058ia, is a fully human recombinant monoclonal antibody with an IgG1 isotype and is suitable as a surrogate positive control or reference standard in an anti-drug antibody (ADA) assay. Additionally, the antibody can be used to develop a pharmacokinetic (PK) bridging assay to measure free drug. It is recommended as the detection antibody, paired with Mouse Anti-Human CD152 Antibody, clone BNI3 ( MCA1724 ) as the capture reagent. Abatacept (Orencia) is a recombinant fusion protein consisting of the extra-cellular domain of human CTLA-4, fused to the modified Fc (hinge, CH2, and CH3 domains) portion of human IgG1. It is used to treat several autoimmune diseases, including rheumatoid arthritis, psoriatic arthritis and juvenile idiopathic arthritis, by inhibiting optimal T-cell activation. It binds to CD80 and CD86 on antigen-presenting cells and blocks the costimulatory interaction with CD28 on T cells. View a summary of all anti-abatacept antibodies

Storage Information
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.