Bio-Rad, MCA6375, AATF antibody | 1B2D8

Rat anti Mouse AATF antibody, clone 1B2D8 recognizes apoptosis-antagonizing transcription factor, also known as Rb-binding protein che-1. AATF was first identified as an RNA pol II – interacting factor ( Fanciulli et al . 2000 ). AATF is a protein encoded by the AATF gene. AATF mediates cellular responses and promotes cell proliferation and survival by inducing autophagy, DNA repair, and cell cycle arrest and inhibiting apoptosis ( Kumar et al . 2019 ). DNA damage leads to phosphorylation of AATF at tyrosine 366 by the MAP kinase-activated protein kinase 2 (MK2) ( Höpker et al . 2012 ). Rat anti Mouse AATF antibody detects a band of 80 kDa.

Storage Information
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended. Should this product contain a precipitate we recommend microcentrifugation before use.