Bio-Rad, TZA097, Benralizumab antibody | AbD59979

Human Anti-Benralizumab (Drug/Target Complex) Antibody, clone AbD59979 specifically recognizes the antibody drug benralizumab when in complex with its target, human interleukin 5 receptor α (IL5Rα ). It does not recognize free benralizumab nor unbound IL-5R. The monovalent Fab format of this antibody, clone AbD59979ad ( TZA097 ) is tagged with a SpyTag2 at the C-terminus of the Fab heavy chain, enabling the user to couple it to a SpyCatcher reagent for conversion to alternative formats in less than one hour. This antibody is also available as a monovalent Fab antibody pre-coupled to the HRP-conjugated SpyCatcher2 ( TZC002P ) under product code TZA097P for direct detection of the benralizumab/ IL5Rα complex in bioanalysis assays. Clone AbD59979 can be used in pharmacokinetic (PK) antigen detection format assays to measure benralizumab that has been captured via immobilized IL5Rα. Benralizumab (trade name Fasenra) is a humanized monoclonal antibody of the IgG1/kappa isotype that binds with high affinity to a conformationally distinct epitope within domain 1°F the α-chain of IL-5R, and thus inhibits proliferation of IL-5-dependent cell lines, and otherwise blocks signaling through the IL-5 receptor. Benralizumab is indicated as a maintenance treatment for severe asthma and an eosinophilic phenotype. View a summary of all anti-benralizumab antibodies

Storage Information
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.