Bio-Rad, VMA00203, ALAS1 antibody | OTI1C5

Mouse anti Human ALAS1 antibody, clone OTI1C5 recognizes ALAS1, also known as 5-aminolevulinate synthase, nonspecific, mitochondrial, 5-aminolevulinic acid synthase 1, ALAS-H, delta-ALA synthase 1, delta-aminolevulinate synthase 1 and migration-inducing protein 4. The ALAS1 gene encodes the mitochondrial enzyme which is catalyzes the rate-limiting step in heme (iron-protoporphyrin) biosynthesis. This enzyme is a housekeeping enzyme; a separate gene encodes a form of the enzyme that is specific for erythroid tissue. The level of the mature encoded protein is regulated by heme: high levels of heme down-regulate the mature enzyme in mitochondria while low heme levels up-regulate. A pseudogene of ALAS1 is located on chromosome 12. Multiple alternatively spliced variants, encoding the same protein, have been identified (provided by RefSeq, Dec 2011). Mouse anti Human ALAS1 antibody, clone OTI1C5 detects a band of 70 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.

Storage Information
This product is shipped at ambient temperature.
Store undiluted at -20°C, avoiding repeated freeze thaw cycles.