Bio-Rad, VMA00963, ARNT antibody | E01/1H8

Mouse anti ARNT antibody recognizes aryl hydrocarbon receptor nuclear translocator, also known as HIF1-beta, bHLHe2. ARNT is a transcription factor which predominantly binds HIF1-alpha or aryl hydrocarbon receptor, forming the heterodimer complex HIF1 which regulates expression of genes involved with a variety of physiological and pathological processes ( Wu et al. 2018 ). Genes activated by HIF have a hypoxia-response element (HRE) within their promoter or enhancer. In this way, ARNT participates in the cellular response to reduced oxygen concentration ( Mandl and Depping 2017 ). Under varying oxygen concentrations in cellular microenvironments, ARNT can also promote cell survival and angiogenesis ( Shieh et al. 2014 ). In cancer, ARNT regulates tumorigenesis by activating genes involved with tumor growth and angiogenesis. Accordingly, ARNT expression has been identified in a range of cancer types and has been suggested as a prognostic biomarker and a target for cancer therapies ( Huang et al. 2015 ).

Storage Information
This product is shipped at ambient temperature.
Store undiluted at -20°C, avoiding repeated freeze thaw cycles