Bio-Rad, VPA00046, Androgen Receptor antibody

Goat anti Human androgen receptor antibody recognizes the human androgen receptor (AR), also known as the dihydrotestosterone receptor or nuclear receptor subfamily 3 group C member 4. AR is a ligand-activated transcription factor that belongs to a large family of nuclear receptor proteins. Unbound AR resides predominately in the cytoplasm as a heteromeric complex with hsp90 and other chaperone proteins. These chaperone proteins maintain AR in a form that is receptive to ligand binding. Upon ligand binding, AR recruits a variety of factors including coactivators and mediator proteins whose enzymatic activities promote chromatin remodeling and transcriptional regulation of target genes leading to cell differentiation, survival, and proliferation. Mutated AR is strongly implicated in development of prostate adenocarcinoma and metastases development. Goat anti Human androgen receptor antibody recognizes androgen receptor as a single band of approximately 110 kDa in LNCaP cell lysates by western blotting under reducing conditions.

Storage Information
This product is shipped at ambient temperature.
Store undiluted at -20°C, avoiding repeated freeze thaw cycles.