Cytiva, 17544403, Capto™ adhere multimodal chromatography resin, 1 L

Capto™ adhere is a strong anioin exchange (AIEX) multimodal chromatography resin designed for purification of monoclonal antibodies (mAbs) after the protein A step at process scale.
It can be used in flow-through or bind/elute mode.
Wide operational window of pH and conductivity.
Resin fulfills industrial demands for security of supply, robust performance, and regulatory support.
Saves time and operating costs when used as part of a two-step chromatographic process with protein A capture.
Removes contaminants to formulation levels.
High capacity and productivity in flow-through mode.
Different selectivity from traditional IEX resins
Capto™ adhere resin is composed of a rigid, high-flow agarose matrix and a novel multimodal ligand. The strong multimodal ligand gives a different selectivity from that of conventional ion exchange (IEX) resins.
Second step in mAb chromatographic process
Capto™ adhere resin can remove key contaminants such as DNA, host cell proteins (HCP), leached protein A, dimers and larger aggregates, and viruses in a single step. Together with a protein A capture step , (using, for example, MabSelect™ SuRe resin ), Capto™ adhere resin allows the design of a two-step chromatographic process for mAbs.
Part of the Capto™ adhere family
For optimal performance of Capto™ adhere, screening and optimization of loading conditions is recommended, preferably using modern high-throughput process development tools, such as PreDictor™ 96-well filter plates.
Prepacked columns and other formats
Capto™ adhere resin is available in the following formats:
Process development scale
PreDictor™ Capto™ adhere filter plates , 96-well plates for high-throughput screening or process development.
PreDictor™ Capto™ adhere RoboColumn units , miniaturized columns for high-throughput process development.
HiScreen™ Capto™ adhere columns , optimized for method and process development.
f (x) column , prepacked and precharacterized chromatography column for fast and accurate mechanistic modeling.
Validation columns , scale-down columns for robust and reproducible process validation and process development (Tricorn™ format)
Lab scale (for manual or automated systems)
HiTrap™ Capto™ adhere columns , for easy use with a syringe, peristaltic pump, or chromatography system.
Process-scale
ReadyToProcess™ Capto™ adhere columns , 1 L and larger columns for clinical manufacturing that minimize the need for cleaning and cleaning validation.
Process characterization kits
Process characterization kits for Capto™ adhere and other resins are designed for studying the potential impact that resin ligand density might have on the process outcome.