Description
General description
Interleukin-22 (IL-22) is a cytokine produced mainly by Th17 cells, as well as by other immune cells such as innate lymphoid cells. It plays a vital role in tissue homeostasis and repair by promoting the survival and proliferation of epithelial cells, particularly in barrier tissues such as the skin and gut. IL-22 is also involved in the immune response to infections and has been implicated in various inflammatory conditions, highlighting its dual role in both protective immunity and pathology.
Application
Inflammatory Disease / Immune Response / Autoimmune Disease
Features and Benefits
Leading Sensitivity: The SMC®technology offers unparalleled performance in the quantification of IL-22 in human serum and plasma, ensuring highly precise measurements.
Standard ELISA Workflow with Digital Precision: Follows a familiar sandwich immunoassay format with a unique elution step that separates labeled antibodies for digital counting, improving signal-to-noise ratio and assay reproducibility.
Advance Inflammation & Mucosal Immunity Studies: IL-22 plays a key role in epithelial barrier function, tissue repair, and host defense. This assay supports research in autoimmune diseases, IBD, psoriasis, and respiratory infections.
Generate Reliable, High-Quality Data: Compatible with FemtoQuest™’s advanced optics and Belysa® Curve Fitting Software, ensuring clean, publication-ready results.
Packaging
96 well assay
Analysis Note
Sensitivity: LLOQ 100 fg/mL* (SMCxPRO® Instrument)
Standard Curve Range: 50-50,000 fg/mL
Intra-assay CV: Inter-assay CV: Linearity: Serum: 110% Plasma: 109%
Recovery: Serum: 106% Plasma: 94%
*Indicative LLOQ created from average of 14 independent in house runs, where >80% met same value defined with CV & Recovery +/- 20%. Refer to CoA for lot specific performance.
Other Notes
Although IL-22 was detectable in non-human primate, mouse, feline and canine samples, the assay has not been verified for these species.
Legal Information
BELYSA is a registered trademark of Merck KGaA, Darmstadt, Germany
FEMTOQUEST is a trademark of Merck KGaA, Darmstadt, Germany
SMC is a registered trademark of Singulex
SMCxPRO is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
