Description
General description
Thymic Stromal Lymphopoietin (TSLP) is a cytokine that plays a critical role in the immune system by promoting the differentiation and activation of various immune cells, particularly dendritic cells and T helper cells. It is primarily produced by epithelial cells in response to environmental stimuli, such as allergens and pathogens, and is involved in the development of allergic responses and asthma. TSLP is considered a key factor in the initiation of Th2 immune responses, making it a potential target for therapeutic interventions in allergic and inflammatory diseases.
Application
Inflammatory Disease / Immune Response / Autoimmune Disease
Features and Benefits
Unmatched Sensitivity: Detects TSLP concentrations down to the femtogram/mL level using SMC®technology, making it ideal for early-stage disease research and low-expression cytokines like TSLP.
High Precision and Accuracy: Provides reproducible and accurate quantification of TSLP, even at very low concentrations, improving confidence in data for preclinical studies.
Facilitates Mechanistic Studies in Airway Epithelium: Enables early-stage immune response tracking, crucial for understanding the initiation of Th2 inflammation and guiding therapeutic development.
Ideal for Translational and Preclinical Research: Supports rare disease models, pediatric studies, and longitudinal sampling, where sample availability is limited but precision is critical.
Packaging
96 well assay
Analysis Note
Sensitivity: LLOQ 1,560 fg/mL* (SMCxPRO® Instrument)
Standard Curve Range: 780-800,000 fg/mL
Intra-assay CV: Inter-assay CV: Linearity: Serum: 111% Plasma: 109%
Recovery: Serum: 113% Plasma: 104%
*Indicative LLOQ created from average of 15 independent in house runs, where >80% met same value defined with CV & Recovery +/- 20%. Refer to CoA for lot specific performance.
Other Notes
Although TSLP was detectable in mouse, canine and some rat and monkey samples, the assay has not been verified for these species.
Legal Information
FEMTOQUEST is a trademark of Merck KGaA, Darmstadt, Germany
SMC is a registered trademark of Singulex
SMCxPRO is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
