Description
General description
Interferon lambda 1 (IFN-λ1), also known as IL-29, is a type of cytokine belonging to the Type III interferon family, which also includes IL-28A and IL-28B. These cytokines are recognized for their role in the immune response against viral infections and are structurally similar to members of the IL-10 family. IL-29 is primarily produced by dendritic cells and is involved in the modulation of antiviral activity, acting similarly to type I interferons, though it interacts with a distinct receptor complex. This cytokine is crucial for its antiviral properties, immune regulation, and potential therapeutic implications in managing viral infections and certain autoimmune disorders. The specific signaling through its receptor can activate various pathways leading to the induction of antiviral state and regulation of immune responses.
Application
Inflammation & Immunology/Inflammatory Disease/Immune Response/Autoimmune Disease
Features and Benefits
Reveal the Invisible: Detect cytokines previously undetectable with standard ELISAs; perfect for early-stage biomarker discovery.
Track Subtle Immune Shifts: Ideal for longitudinal studies, viral infection models, and autoimmune research.
Trusted Quality: Backed by robust support and verified reagents.
Wide Dynamic Range: Quantifies IL-29 across 130–200,000 fg/mL, capturing both subtle and robust immune responses.
Packaging
96 well assay
Analysis Note
Sensitivity: LLOQ 260 fg/mL* (SMCxPRO® Instrument)
Standard Curve Range: 130-200,000 fg/mL
Intra-assay CV: Inter-assay CV: Linearity: Serum: 115% Plasma: 109%
Recovery: Serum: 85% Plasma: 95%
*Indicative LLOQ created from average of 14 independent in house runs, where >80% met same value defined with CV & Recovery +/- 20%. Refer to CoA for lot specific performance.
Other Notes
IFNλ1 was not cross-reactive with non-human primate, rat, mouse, feline or canine samples.
Legal Information
FEMTOQUEST is a trademark of Merck KGaA, Darmstadt, Germany
SMC is a registered trademark of Singulex
SMCxPRO is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
