Merck, 1000022500, Tri-n-butyl phosphate

Name: Tri-n-butyl phosphate
Brand: Merck
SKU: 1000022500

Size:2.5 L, Tributyl phosphate, TBP, TBPA, EMPROVE® EXPERT, Ph. Eur.

Catalog Number: 1000022500

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Category

Virus Inactivation Reagents

Pack Size2.5 L

TagsChemistry & Biochemicals Formulation Biomolecule Formulation

CollectionsMerck Cell Culture Supplements & Reagents: Complete Solutions for Research & Bioproduction Merck Roche Life Science Products for PCR, RT‑PCR & Nucleic Acid Purification

Description

General description
Chemicals play an important role in the stabilization of a biologic drug during its manufacturing and formulation process – for instance, by preventing aggregation. We offer a wide range of high-quality stabilizers, buffers and salts to successfully purify and formulate your biomolecules. Specifically developed for high-risk applications, they are low in bioburden and endotoxins.
As part of our Emprove® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.
Application
Tri-n-butyl phosphate is used widely as a solvent along with either TritonTM X100 or Tween® in solvent detergent treatment for viral inactivation procedures especially for plasma derived therapeutics.
Due to its low microbial and endotoxin limits, Tri-n-butyl phosphate Emprove® Expert is especially suitable for high-risk applications.
Legal Information
Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany
SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany
TWEEN is a registered trademark of Croda International PLC

Specifications

General

EC Index Number	204-800-2
UNSPSC Code	12352303
Beilstein/REAXYS Number	1710584
MDL number	MFCD00009436
SMILES string	CCCCOP(=O)(OCCCC)OCCCC
InChI	1S/C12H27O4P/c1-4-7-10-14-17(13,15-11-8-5-2)16-12-9-6-3/h4-12H2,1-3H3
InChI key	STCOOQWBFONSKY-UHFFFAOYSA-N
agency	Ph. Eur.
vapor density	9.2 (vs air)
vapor pressure	27 mmHg ( 178 °C)
product line	EMPROVE® EXPERT
form	liquid
autoignition temp.	770 °F
Quality Level	500
refractive index	n20/D 1.424 (lit.)
bp	180-183 °C/22 mmHg (lit.)
mp	−79 °C (lit.)
transition temp	flash point 146 °C
solubility	6 g/L
density	0.979 g/mL at 25 °C (lit.)
application(s)	liquid formulationpharma/biopharma processespharmaceutical
storage temp.	15-25°C

FAQs

Question: What is the intended process application of tri-n-butyl phosphate?

Answer:It is an organic phosphate ester used in solvent/detergent viral inactivation processing with a compatible detergent and validated conditions.

Question: How much tri-n-butyl phosphate is supplied?

Answer:The EMPROVE EXPERT Ph Eur product is supplied in a 2.5 L glass bottle.

Question: Can tri-n-butyl phosphate alone validate viral inactivation?

Answer:No. Viral inactivation requires a defined solvent/detergent formulation, qualified process parameters and process-specific validation; the reagent alone does not establish clearance.

Application Note

Merck Tri-n-butyl Phosphate EMPROVE EXPERT is an organic phosphate ester used as a process chemical in biopharmaceutical manufacturing, particularly solvent/detergent treatment workflows. This product meets a Ph Eur grade designation and is supplied as 2.5 L in a glass bottle. Tri-n-butyl phosphate (TBP; CAS 126-73-8) is hydrophobic and must be handled as a chemical processing agent rather than an aqueous buffer component. In solvent/detergent viral inactivation processes, TBP is typically combined with a compatible detergent at defined concentrations and under validated contact conditions. The compound's identity and controlled manufacturing documentation help support raw-material qualification and process traceability. Selection must consider the process fluid, mixing efficiency, exposure time and downstream clearance of process additives. For manufacturing use, assess the safety data, compatibility and removal strategy alongside the established virus-inactivation validation protocol.

Ordering

Notice

Unless otherwise stated, the minimum order amount is USD 1,000.
For orders below USD 1,000, an additional handling fee may apply, or we may arrange local delivery / local handover where available.
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