Merck, 104678, Cellvento®ModiFeed Gal+ COMP

General description
Cellvento® ModiFeed Gal+ COMP is part of the ModiFeed platform for process optimization in fed-batch. It is a highly concentrated, one-part, pH neutral feed added to replenish depleted nutrients required for cellular function and to extend the production phase in fed-batch mode, while simultanously maximizing galactosylation on the protein of interest. It is recommended in combination with the production media Cellvento® 4CHO and EX-CELL® Advanced CHO Fed-batch medium or other production media.
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Application
Glycosylation is known to have effects on the biological activity, solubility, serum half-life, and saftey of therapeutic proteins. Control of protein glycosylation processes, such as galactosylation, while maximizing productivity is key for successful mAb process development and production. Cellvento® ModiFeed Gal+ COMP was developed to increase galactosylation while maintaining or improving titer in CHO fed-batch processes.
Features and Benefits
Reduced complexity in fed-batch process
Complete feed maximizing galactosylation
Highly concentrated to reduce required feed volume
Compacted format for conventient handling
Higher liquid feed stability at room temperature

Preparation Note
Formulated to contain 159.9 grams of powder per liter of feed.
Legal Information
CELLVENTO is a registered trademark of Merck KGaA, Darmstadt, Germany
EX-CELL is a registered trademark of Merck KGaA, Darmstadt, Germany
Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany