Description
General description
A cell-permeable and reversible inhibitor of protein kinase A (Ki = 11 µM). Resistant to hydrolysis by phosphodiesterases. Noncompetitive with respect to ATP.
Cell permeable inhibitor of protein kinase A (Ki = 11 µM). Resistant to hydrolysis by phosphodiesterases. Note: 5 µmol = 2.23 mg
Note: 5 µmol = 2.23 mg.
Biochem/physiol Actions
Cell permeable: yes
Primary Target
PKA
Product does not compete with ATP.
Reversible: yes
Target Ki: 11 µM against protein kinase A
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Other Notes
Kaji, H., et al. 1992. Biochem. Biophys. Res. Commun. 182, 1356.
Van der Kloot, W., and Branisteanu, D.D. 1992. Eur. J. Phys.420, 336.
Yokozaki, H., et al. 1992. Cancer Res.52, 2504.
Butt, E., et al. 1990. FEBS Lett.263, 47.
Dostmann, W.R., et al. 1990. J. Biol. Chem.265, 10484.
Rothermel, J.D. 1988. Biochem. J. 251, 757.
Eckstein, F. 1985. Annu. Rev. Biochem.54, 367.
de Wit, R.J., et al. 1984. Eur. J. Biochem.142, 255.
O′Brian, C.A., et al. 1982. Biochemistry21, 4371.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)