Merck, 124013-2MG, Akt Inhibitor VI, Akt-in

General description
A reversible 15-mer peptide derived from proto-oncogene TCL1 (amino acids 10-24) that acts as a specific inhibitor of Akt. Shown to bind to Akt-PH domain (Kd ~18 µM) and interfere with the Akt-phosphoinositide interaction, thus hindering membrane translocation from the cytosol and downstream biological responses.
A reversible 15-mer peptide derived from the amino acids 10-24 of the proto-oncogene TCL1 (TCL₁₀₋₂₄) and acts as a specific inhibitor of Akt. Shown to bind to the Akt-PH domain (Kd ~18 µM) and interfere with the Akt-phosphoinositide interaction. This peptide, when made cell-permeable (Cat. No. 124014), has been shown to hinder Akt membrane translocation from the cytosol and subsequent downstream biological responses.
Biochem/physiol Actions
Cell permeable: no
Kd ~18 µM in binding to Akt-PH domain
Primary Target
Akt
Product does not compete with ATP.
Reversible: yes
Packaging
Packaged under inert gas
Physical form
Supplied as an acetate salt.
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes
H-Ala-Val-Thr-Asp-His-Pro-Asp-Arg-Leu-Trp-Ala-Trp-Glu-Lys-Phe-OH
Hiromura, M., et al. 2004. J. Biol. Chem.279, 53407.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Carcinogenic / Teratogenic (D)