Merck, 14-593-M, HePTP Protein, 250 µg

General description
40.7kDa
FUNCTION: SwissProt: P35236 # Protein phosphatase that acts preferentially on tyrosine-phosphorylated MAPK1. Plays a role in the regulation of T and B-lymphocyte development and signal transduction.
SIZE: 360 amino acids; 40529 Da
SUBUNIT: Monomer. Interacts with MAPK1, MAPK3 and several other MAP kinases.
SUBCELLULAR LOCATION: Cytoplasm.
TISSUE SPECIFICITY: Expressed exclusively in thymus and spleen.
PTM: Phosphorylated on serine residues in resting T-cells. Phosphorylation increases upon exposure to stimuli that increase intracellular cAMP levels. Phosphorylation leads to dissociation of bound MAP kinases.
SIMILARITY: SwissProt: P35236 ## Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily. & Contains 1 tyrosine-protein phosphatase domain.
Packaging
Also available in 250 µg size --call for pricing and availability and reference catalog number 14-593M when ordering the 250 µg size.
Also available in 10 μg size (cat#14-593) and in bulk (cat# 14-593-K).
Preparation Note
6 months at -70°C from date of shipment
Analysis Note
For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
routinely evaluated by dephosphorylation of 100μM DiFMUP
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.