Description
General description
A 452-amino acid glycoprotein present in plasma at about 70 µg/ml. Efficiently inhibits the plasminogen activator-induced lysis of fibrin clots. Forms a covalent complex with plasmin and inactivates it.
Biochem/physiol Actions
Cell permeable: no
Primary Target
Plasminogen activator-induced lysis of fibrin clots
Product does not compete with ATP.
Reversible: no
Physical form
Lyophilized from 200 mM NaCl, 20 mM Bis-Tris, pH 6.4.
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Please refer to the vial label for the lot-specific reconstitution volume.
Prepared from plasma that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
Other Notes
One Inhibitory Unit (I.U.) is defined as the amount of enzyme that will inhibit 1 unit plasmin activity using tosyl-Gly-Pro-Lys-pNA as substrate at 25°C, pH 7.8
Schaefer, B.M., et al. 1996. Arch. Dermatol. Res. 288, 122.
Aoki, N., et al. 1980. Blood 55, 483.
Saito, H., et al. 1974. Circ. Res.34, 641.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
Toxicity: Standard Handling (A)
