Merck, 208724-1MG, Calpain Inhibitor IV

General description
A potent, cell-permeable and irreversible inhibitor of calpain II (k₂ = 28,900 M⁻¹s⁻¹). Also acts as an inhibitor of cathepsin L (k₂ = 680,000 M⁻¹s⁻¹).
A potent, cell-permeable, and irreversible inhibitor of calpain II (k₂ = 28,900 M⁻¹s⁻¹). Also acts as an inhibitor of cathepsin L (k₂ = 680,000 M⁻¹s⁻¹).
Biochem/physiol Actions
Product does not compete with ATP.
Reversible: no
Cell permeable: yes
Primary Target
calpain 2
k₂ = 28,900 M⁻¹s⁻¹ in the inhibition of calpain II; k2 = 680,000 M⁻¹s⁻¹ in the inhibition of cathepsin L
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Analysis Note
single spot by TLC
Other Notes
Dutt, P., et al. 1998. FEBS Lett. 436, 367.
Angliker, H., et al. 1992. J. Med. Chem. 35, 216.
Z-Leu-Leu-Tyr-CH₂F
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)