Merck, 219385-1MG, Cathepsin B Inhibitor II

General description
A more active lysinal analog of Leupeptin (Cat. No. 108975). A more potent inhibitor of cathepsin B (IC₅₀ = 4 nM) compared to leupeptin (IC₅₀ = 310 nM).
Lysinal analog of Leupeptin (Cat. No. 108975). A more potent inhibitor of cathepsin B (IC₅₀ = 4 nM) than of leupeptin (IC₅₀ = 310 nM). Note: this peptide forms cyclic isomers.
Note: this peptide forms cyclic isomers.
Biochem/physiol Actions
Cell permeable: no
Primary Target
cathepsin B
Product does not compete with ATP.
Reversible: no
Target IC₅₀: 4 nM against cathepsin B
Preparation Note
Following reconstitution aliquot and freeze (-70°C). Stock solutions are stable for up to 1 month at -70°C.
Other Notes
Ac-Leu-Val-lysinal
McConnell, R.M., et al. 1993. J. Med. Chem. 36, 1084.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)