Merck, 219419-1MG, Cathepsin Inhibitor III

General description
Cysteine protease inhibitor. Selectively inhibits cathepsin B (k₂/Ki = 1.0 x 10⁴ M⁻¹sec⁻¹), cathepsin L (k₂/Ki = 1.5 x 10⁵ M⁻¹sec⁻¹), cathepsin S (k₂/Ki = 6.6 x 10⁴ M⁻¹sec⁻¹), and papain (k₂/Ki = 1.0 x 10³ M⁻¹sec⁻¹). Half-life in buffered solution (pH 5-9) = 37 h (30°C); 300 h (0°C).
Half-life in buffered solution (pH 5-9) = 37 h (30°C); 300 h (0°C).
Biochem/physiol Actions
Cell permeable: no
Primary Target
cathepsin B
Product does not compete with ATP.
Reversible: no
k₂/Ki = 1 x 10⁴ M⁻¹ sec⁻¹
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Demuth, H.-U., et al. 1996. Biochim. Biophys. Acta1295, 179.
Brömme, D., and Demuth, H.-U. 1994. Methods Enzymol. 244, 671.
Z-Phe-Gly-NHO-Bz-pOMe
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)