Merck, 223A-16-RUO, A-1-Antitrypsin Rabbit Polyclonal Antibody

General description
Alpha-1-Antitrypsin is a protease inhibitor from the serpin superfamily, which inhibits a number of protease enzymes from inflammatory cells. It is an acute-phase plasma protein predominantly produced in hepatocytes, although it is also made in enterocytes and some mononuclear white blood cells. Alpha-1-antitrypsin immunohistochemistry is used to detect the accumulation of alpha-1-antitrypsin in hepatic lesions and histiocytic tumors.
The immunohistochemical staining of Alpha-1-Antitrypsin is considered to be very useful in the study of inherited AAT deficiency, benign and malignant hepatic tumors, and yolk sac carcinomas. Positive staining for A-1-Antitrypsin may also be used in the detection of benign and malignant lesions of a histiocytic nature. The sensitivity and specificity of the results have made this antibody a useful tool in the screening of patients with cryptogenic cirrhosis or other forms of liver disease with portal fibrosis of uncertain etiology.
Physical form
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide
Preparation Note
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Analysis Note

IVD

IVD

IVD

RUO

Other Notes
A-1-Antitrypsin Positive Control Slides , Product No. 223S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).
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Legal Information
Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany