Merck, 233493-500UG, Coagulation Factor α-XIIa, Human Plasma

General description
Native coagulation factor α-XIIa from human plasma prepared from homogeneous Factor XII using dextran sulfate. Dextran sulfate is removed after activation. α-XIIa is a serine protease responsible for activation of Factor XI to Factor XIa. Factor XIIa and prekallikrein are thought to be involved in a reciprocal activation mechanism whereby Factor XIIa activates prekallikrein to kallikrein, which in turn converts Factor XII to Factor XIIa.
Packaging
Please refer to vial label for lot-specific concentration.
Physical form
In 150 mM NaCl, 4 mM sodium acetate buffer, pH 5.3.
Preparation Note
Following initial thaw, aliquot and freeze (-70°C).
Prepared from plasma that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
Analysis Note
Clotting activity is determined by comparison to a standard curve produced using normal pooled human plasma
homogeneous by SDS-PAGE
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)