Merck, 238900-5MG, 4-Cyano-3-methylisoquinoline

General description
A potent, cell-permeable, reversible, and specific inhibitor of protein kinase A (IC₅₀ = 30 nM). Inhibition is competitive with respect to ATP. Shows only weak inhibitory activities against Ca²⁺-dependent protein kinase (CDPK), MLCK, PKC, and cyclic nucleotide-binding phosphatase.
A potent, cell-permeable, specific inhibitor of protein kinase A (PKA; IC₅₀ = 30 nM). Inhibition is competitive with respect to ATP. Shows only weak inhibitory activities against Ca²⁺-dependent protein kinase (CDPK), MLCK, PKC, and cyclic nucleotide-binding phosphatase (Pase).
Biochem/physiol Actions
Cell permeable: yes
Primary Target
PKA
Product competes with ATP.
Reversible: yes
Target IC₅₀: 30 nM against protein kinase A
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Other Notes
Lu, Z.X., et al. 1996. Biol. Chem. Hoppe Seyler 377, 373.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)