Merck, 260585-50MG, 5′-Deoxy-5′-methylthioadenosine

General description
A cell-permeable, reversible, and ATP-competitive naturally-occurring co-product of polyamine biosynthesis that acts as an endogenous substrate of methylthioadenosine phosphorylase (MTAP). Potently inhibits the protein carboxymethyltransferase and induces apoptosis in leukemia U937 cells. Also inhibits FGF-2 receptor tyrosine kinase activity as well as the proliferation of human astrocytes and glioma cells.
A naturally occurring co-product of polyamine biosynthesis that acts as an endogenous substrate of methylthioadenosine phosphorylase (MTAP). A cell-permeable, reversible, and ATP-competitive inhibitor of protein carboxymethyltransferase and induces apoptosis in leukemia U937 cells. Also acts as an inhibitor of NGF-induced tyrosine phosphorylation in PC12 cells and blocks FGF-2 receptor tyrosine kinase in astrocytes and glioma cells.
Biochem/physiol Actions
Primary Target
protein carboxymethyltranferase
Secondary Target
FGF-2receptor tyrosine kinase activity
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 1 month at -20°C.
Other Notes
Lee, S.H., and Cho, Y.D. 1998. Exp. Cell Res.240, 282.
Smalheiser, N.R. 1998. Brain Res. Dev. Brain Res.51, 53.
Joy, A., et al. 1997. Oncogene14, 171.
Riscoe, M.K., et al. 1984. Biochem. Pharmacol.33, 3639.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Irritant (B)