Description
General description
Binds covalently and irreversibly to the outer surface of human erythrocyte membrane proteins. Inhibits ATP transport into the endoplasmic reticulum vesicles. Anion transport inhibitor that inhibits Cl⁻ uptake (IC₅₀ = 150 nM) in neuroblastoma cells. Has antiulcerous activity.
Biochem/physiol Actions
Cell permeable: no
Primary Target
Cl- uptake
Product does not compete with ATP.
Reversible: no
Target IC₅₀: 150 nM inhibiting Cl- uptake in neuroblastoma cells
Other Notes
Bettendorff, L., et al. 1995. Biochem. Biophys. Res. Commun. 207, 375.
Horie, S., et al. 1993. Res. Commun. Chem. Pathol. Pharmacol. 79, 117.
Mayinger, P., and Meyer, D.I. 1993. EMBO J. 12, 659.
Catantchik, Z.I., and Rothstein, A. 1974. J. Membr. Biol.15, 207.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Irritant (B)